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But the same 2025 review that catalogs those effects also underscores that only three human clinical trials have been published and that the compound remains investigational, with regulators having flagged it precisely because human safety and efficacy are not established

Contributions to Nephrology

It means getting 1000 mcg (1 mg) of B12 injected once a week

The present study revealed that both high-dose paraxanthine (PXN HIGH) and high-dose caffeine (CAF HIGH) significantly increased neurotransmitters involved in learning and memory, including acetylcholine, dopamine, and GABA

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