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Lead author Professor Sunil Badve, professorial fellow at The George Institute for Global Health and UNSW Sydney, said the study expanded current knowledge about the drugs in key areas, including benefits in people with chronic kidney disease (CKD), and in people with and without diabetes

While 80% of women with PCOS have BMI values above normal or high, the rest present with what is known as a lean phenotype, according to research published in the Journal of Diabetes & Metabolic Disorders

Of interest, treatment of aged rats with IGF-I was shown to upregulate eNOS and improve bioavailability of NO[295], and in vitro experiments in cultured endothelial cells demonstrated that IGF-I treatment reduce ROS production and upregulate eNOS[294]