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Reduced activity of AMP-activated protein kinase protects against genetic models of motor neuron disease
In adulthood, ROS contribute to immune responses, tissue repair, and adaptation to environmental challenges
Combining ferroptosis inducers with immune checkpoint inhibitors, such as anti-CTLA4 (cytotoxic T-lymphocyte associated protein 4), anti-PDCD1/PD-1 (programmed cell death 1), or anti-CD274/PD-L1 (programmed death ligand 1) antibodies, enhances tumor suppression compared to using immune checkpoint inhibitors alone