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Cysteine and homocysteine metabolism are influenced by dietary factors, including the intake of methionine, vitamins (B6, B12, folate), and other nutrients

These ROS oxidize PUFAs in cell membranes into lipid peroxides (PUFA-OOH), thereby destroying cell membrane structural stability, attacking cellular DNA and proteins, and causing ferroptosis

Milella M, Ricciardi MR, Gregorj C, De Cave F, Abrams SL, Steelman LS, Chiaretti S, Konopleva M, Petrucci MT, Cognetti F, Foa R, Andreeff M , McCubrey J, Tafuri A

Weight regain is a common phenomenon after discontinuation of GLP-1 RAs, suggesting that the therapeutic benefits largely depend on treatment and subsequent management

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