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For acute injuries, the traditional RICE protocol (rest, ice, compression, elevation) emphasizes immediate cold application during the first 48 hours when inflammatory processes are most active

Cold serum can be uncomfortable on skin and may absorb less effectively

One of the important research results is that it allows cells to move in fast to repair damaged tissue areas while also promoting the formation of new blood vessels, a process known as angiogenesis

Progesterone is often sedating, which is helpful for insomnia, but may not be tolerated by everyone