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It does not, and the FDA's reasoning here is worth taking seriously

Standard dosing (2mg daily) Most clinical protocols and research applications use 2mg as the standard daily dose

If you are extremely sensitive and find that taking the supplement on a completely empty stomach causes mild nausea, clinical evidence suggests pairing it with a very small, light snack (such as a few bites of fruit or a cracker) can mitigate digestive discomfort while still preserving the stability of the acetylated molecule

More than folate absorption, the MTHFR gene is also heavily involved in the process of methylation which is responsible for converting homocysteine into methionine, a substance the body needs for proper metabolism and muscle growth and which is needed for glutathione creation

Consider the human evidence base for BPC-157 in full