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Deciphering mitochondrial dysfunction in keratoconus: insights into acsl4 from machine learning-based bulk and single-cell transcriptome analyses and experimental validation

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Together these observations are consistent with an important concept: microglia are the earliest responders to a primary multifocal myelin injury in the MS white matter, and importantly, this injury/response seems to precede lymphocytic infiltration, arguing against adaptive immune cells being the primary drivers of white matter injury

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