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When the T-cell receptor of these potentially autoreactive CD4 and CD8 T cells encounters the auto/self-peptide in the grooves of the two HLA molecules expressed on the plasma membrane of the medullary thymic epithelial cells, the autoreactive T cells receive the kiss of death and more than 90% of them die by apoptosis in the first days of life

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The majority of AR binding sites (ARBSs) are found in enhancer and intergenic regions rather than in gene promoters, and long-distance interactions occur via chromatin looping between AR bound at AREs at different regions (enhancers versus promoters) of the same AR target gene [53]