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However, lipid infusion is not a physiological model, and as highlighted in Table 2, there is a significant gap in the literature regarding the effects of diet-induced insulin resistance on skeletal muscle MBF in humans

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This also increases local blood flow to the muscles, thereby improving substrate utilization

With heart disease being the leading cause of death in the U.S., and obesity as the leading cause of heart disease, these drugs bring a lot of promise to two of Americas most-pressing health problems

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