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In mammals, their generation from metal-loaded metallothioneins can occur by means of -elimination processes involving the several binding cysteines, according to a chemical mechanism analogous to that leading to the decomposition of glutathione-metal conjugates and leading to the production of the dehydroalanine analogue of glutathione

Chronic cerebral hypoperfusion-induced impairment of a clearance requires HB-EGF-dependent sequential activation of HIF1 and MMP9

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