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Long-term follow-up of patients has not validated these concerns

The effectiveness of the orobuccal route for glutathione administration in rapidly achieving high serum concentrations is well documented

Recent studies have demonstrated that p53 contributes to iron homeostasis by transcriptionally regulating the expression of solute carrier family 25 member 28 (SLC25A28) and ferredoxin reductase (FDXR) to enhance the susceptibility of cells to ferroptosis [127, 128]

1 Helmholtz Center Munich, Munich, Germany, 2 Helmholz Center Munich, Neuherberg, Germany, 3 Helmholtz Center Munich, Neuherberg, Germany, 4 Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany

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