The biological significance of MT-1 as a research compound rests on its selectivity profile within the melanocortin receptor family , while native -MSH activates MC1R, MC3R, MC4R, and MC5R with overlapping potency, MT-1s structural modifications confer preferential activity at MC1R relative to the centrally expressed MC3R and MC4R subtypes, making it a more MC1R-selective research tool than either the native peptide or Melanotan II
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Mantilla-Escalante DC, de Las L, Hazas MC, Crespo MC, Martn-Hernndez R, Tom-Carneiro J, Del Pozo-Acebo L, Salas-Salvad J, Bull M, Dvalos A (2021) Mediterranean diet enriched in extra-virgin olive oil or nuts modulates circulating exosomal non-coding RNAs