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However, post-eradication, new PV vaccines will be required that are not derived from an infectious virus, such as virus-like particle (VLP) vaccines utilising the capacity for recombinantly expressed capsid proteins to self-assemble into empty viral capsids 11

This suggests that the drastic inhibition of GLP-1 secretion by shutdown of the main pathway via the SSTRs-Gi axis is the primary cause of pasireotide-induced hyperglycemia

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The dosing and titration schedule remain identical