Grape seed procyanidin activates peroxisome proliferator-activated receptor (PPAR), thereby downregulating the expression of cyclooxygenase 2 (COX-2), achieving the regulation of lipid metabolism, inhibiting cell proliferation, blocking the inflammatory cascade, alleviating vascular inflammation, and reversing the vascular structural remodeling of PASMCs (Liu et al., 2020)
Eur J Clin Nutr 64(11):13381343 Stead LM, Brosnan JT, Brosnan ME, Vance DE, Jacobs RL (2006) Is it time to reevaluate methyl balance in humans
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