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Our prior work has focused primarily on targeted degradation of the methyltransferase and methyl-lysine binding protein NSD2, which is an oncogene and a high value therapeutic target in several cancers including multiple myeloma, acute lymphocytic leukemia, and prostate cancer 15,16,17,18,19

P values indicated, determined by two-tailed t -test ( a ) or one-way ANOVA with Dunnetts multiple comparisons test against CTRL ( b )

This sparked further advancements, including Novo Nordisks development of more potent analogs like liraglutide and semaglutide, with the latter achieving over $12 billion in sales by 2022

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