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A serotonin 5-HT 2A receptor antagonist was shown to reduce neuronal proliferation, and chronic administration of a 5-HT 1A receptor agonist increased neuronal proliferation (Jha et al., 2008)

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Safety Considerations and the Importance of Monitoring While growth hormone peptides are generally well-tolerated, they are powerful biological messengers that require careful monitoring

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2 Methodology This review was conducted through a literature search in PubMed, Scopus, Web of Science and Google Scholar, using combinations of keywords such as Parkinsons disease, -synuclein aggregation, sirtuins, insulin signaling, GLP-1 and incretin mimetics phytomolecules, neuroprotection, and therapeutics. The search covered publications from 2010 to January 2026