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However, along with the rapid titration schedule came gastrointestinal side effects, especially nausea and vomiting, which were the most common reason for discontinuation

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In contrast, while the dose-response relationship between -cell responsiveness to glucose (expressed as the slope of the linear relation between insulin secretion rate and the glucose concentration) and GLP-1 levels in circulation is partially impaired a phenomenon referred as GLP-1 resistance (62) a therapeutic infusion of GLP-1 at a pharmacological dose can restore -cell insulin secretion responsiveness to glucose levels comparable to those observed in nondiabetic individuals (62)

Refining the use of adjuvant oxaliplatin in clinical stage II or III rectal adenocarcinoma