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In-Vitro & Cellular Studies Laboratory experiments using cell cultures and isolated tissues have explored molecular and cellular mechanisms associated with: angiogenesis-related signaling fibroblast migration and behavior extracellular-matrix organization actin cytoskeleton interactions (TB4-related) inflammatory mediator expression These studies help identify biological pathways but do not replicate the complexity of whole-organism responses

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Results from Figure 2A confirmed that FOXO4-DRI killed the cells through inducing apoptosis