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This causes excessive calcium to enter neurons, damaging mitochondria and triggering cell death (Prasad et al., 2019)

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Cardiometabolic outcome trials Older women taking orlistat had improved biventricular diastolic function and beneficial restructuring of their myocardium, producing a lower left ventricular mass, at the end of 6 months, although the cardiac outcomes were likely the result of weight loss rather than independent effect of orlistat [105]