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N Engl J Med 375 , 18341844 (2016)

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Evidence base : Semaglutide has been studied in large, randomized controlled trials involving tens of thousands of patients, with well-established safety and efficacy profiles

This can result in a reduced need for thyroid hormone replacement, particularly in patients who initially required higher doses due to obesity-related factors like increased inflammation or altered hormone metabolism

Concurrently, significant shifts in bile acid metabolism were observed, suggesting that BBRs efficacy arises from the interplay between microbial, metabolic, and epithelial pathways [109]