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Among the monoclonal antibodies, rituximab (specific to the calcium-channel protein CD20 on the surface of B cells and mature plasma cells) increases ROS and induces apoptosis via the inhibition of Bcl-2 and p38MAPK signaling and is used in the treatment of B cell lymphomas 91

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Up-regulation of 91H promotes tumor metastasis and predicts poor prognosis for patients with colorectal cancer

J Hum Genet 55:565570