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The EMPA-REG OUTCOME trial was a long-term, multicenter, randomized, double-blind, placebo-controlled trial of more than 7,000 patients from 42 countries with type 2 diabetes at high risk for cardiovascular events

investigated rapamycin pharmacokinetics following a single oral dose of 0.1 mg/kg or a five-day course of this treatment.[51] In the single-dose protocol, rapamycin concentration peaked twice, at two- and six-hours post-administration, but this pattern was not noted when the dogs were treated on five consecutive days

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This is sometimes referred to as the fertile window