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In total, they studied 30 people who stayed on a reduced dose, 21 of whom were on tirzepatide (Mounjaro and Zepbound) and nine on semaglutide
Combining these medications can precipitate acute withdrawal symptoms, including severe nausea, vomiting, and abdominal cramping
These mice also exhibited significantly reduced insulin secretion, indicating that normal glucagon secretion is necessary to maintain appropriate insulin secretion [14, 21]