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In practical terms, low energy availability may contribute to: Slower muscle and tendon remodeling Reduced tolerance to training volume Delayed strength progression during rehabilitation Higher perceived fatigue Increased risk of overuse symptoms Longer timelines to return to sport at full performance capacity For physical therapists and sports medicine clinicians, this matters more than ever

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However, a high-resolution karyotype is still needed to detect cases with translocations or other rare chromosomal rearrangements involving chromosome 15 ( 1.2 Endocrine features It is important to note that PWS undergoes a complex evolution throughout an individuals lifespan

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