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In the HPS2-THRIVE study, also no additional clinical benefit was observed from treatment with prolonged-release niacin and laropiprant (a compound that inhibits prostaglandin D2 synthesis responsible for skin flushing and hot flashes) in combination with a statin [204]

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Therefore, -cell failure is considered to play a major role in the pathogenesis of the disease

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Another factor to consider in an in vitro neutralization assay is the length of time for which the antibody is preincubated with the virus

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