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The result is a catch-22: patients must persist long enough to demonstrate clinical benefit, yet the financial burden often prevents that persistence, undermining the very outcomes needed to justify reimbursement

You have some wiggle room, but if you fall off your schedule for too long, those signs of fatigue will inevitably return, and they almost always arrive on the scene before any other symptom does

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Moreover, significant degeneration of NE neurons in the LC can also exacerbate the neuroinflammatory process in PD (109)

DrWS: All the literature and information that started on peptides really began with insulin