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It was first isolated from human plasma in 1973 by Loren Pickart, and the tripeptide has since been identified in human saliva and urine
de Farias, C
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Peroxynitrite is highly toxic to neurons and causes hyper-excitability of the central nervous system, a process known as "kindling." This leads to autonomic nervous system dysfunction (dysautonomia), sensory overload, and severe cognitive deficits
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