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It was first isolated from human plasma, where it naturally occurs at concentrations of around 200 ng/mL at age 20, declining to approximately 80 ng/mL by age 60

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Clinical implication Clinicians are encouraged to perform comprehensive evaluations prior to prescribing GLP-1 RA therapy in patients with a history of pancreatic disorders or other pancreatitis risk factors

The remaining authors disclose no conflicts

Originally developed for type 2 diabetes management, it gained FDA approval for chronic weight management under the brand name Wegovy after landmark clinical trials demonstrated results that reshaped how the medical community thinks about obesity treatment