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Gut-brain connection: microbiome, gut barrier, and environmental sensors

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At low JA-Ile levels, the transcription of JA-responsive genes is repressed because of the accumulation of JAZ proteins, but this repressed state is de-repressed by JA-Ile levels elevated in response to environmental and developmental cues, which promote the binding of JA-Ile with JAZ in the COI1 coreceptor and initiate ubiquitination and the subsequent degradation of JAZ by proteasomes

Green tea ( Camellia sinensis ) owes its antioxidant efficacy to a family of polyphenolic catechins, principally EGCG, epicatechin gallate, epicatechin-3-gallate, and epigallocatechin, as well as anthocyanins, gallic acid derivatives, vitamins C and E, and trace minerals including selenium and zinc 39,40,41,42