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Human mesenchymal stromal cell source and culture conditions influence extracellular vesicle angiogenic and metabolic effects on human endothelial cells in vitro
Preliminary program results are promising: ~1,500 clients have enrolled in the program since the program launched in April 2023, including: 61% of commercial employer-sponsored lives 17% of commercial health plan lives ** 67% of members meet smart logic criteria and do not require submission of a PA request 84% of PA requests result in denial, and 72% overall target fill rate *** ~$1B or ~$4.86 PMPM in client savings 3 These drugs are being studied in both weight- and non-weight-related conditions
Aging leads to impaired upregulation of ICOS in response to allostimulation
The SELECT trial demonstrated a 20% reduction in major adverse cardiovascular events in 17,604 adults with preexisting cardiovascular disease, overweight or obesity, without diabetes [1] [2]
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