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Kidney injury appears only as a secondary effect of dehydration from severe gut upset. Anti-drug antibodies form in roughly half to two-thirds of users but do not affect clearance, weight, or blood sugar. Benefits that look like side effects Tirzepatide lowers uric acid (about -0.7 to -1.0 mg/dL, mostly through weight loss) and lowers blood pressure

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References Bell CJM, Mehta M, Mirza L, Young AH, Beck K

104 Overall, as the exact role of inflammation in AIH remains unclear, its use as a therapeutic target is controversial

And thats something that happens as well because visceral fat is surrounding the liver