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Frankel AD, Pabo CO

Gupta et al., 2010

human data limited If Pregnancy Occurs : Stop medication immediately

Emerging evidence suggests that a healthy gut microbiome, supported by tea polyphenols, can produce short-chain fatty acids

When to Suspect APD APD should be suspected when: Skin symptoms recur monthly despite standard dermatologic treatment Symptoms reliably worsen before menstruation Reactions appear after starting progesterone or progestins Antihistamines provide partial but not complete relief Related: Histamine Intolerance: What It Is & What to Do About It APD Causes and Risk Factors APD develops due to an autoimmune response to progesterone, though the exact mechanism of this hypersensitivity is not fully understood