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Statements Author contributions PG: Data curation, Methodology, Writingoriginal draft, Writingreview and editing, Investigation

The overall length of the tubule (L) was calculated by multiplying the tubules total volume by its length density (LV) [39]

Selenium Selenium is an essential cofactor for key enzymes in cellular metabolism, including antioxidant enzymes thioredoxin reductase (TrxR), glutathione peroxidase (GPx), iodothyronine deiodinases (DIOs), and selenoprotein P, all crucial for a correct thyroid function [63, 64]

For references and more information , see the section on heart failure in the L-carnitine article