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The downstream effects of enhanced GH secretion include increased production of insulin-like growth factor-1 (IGF-1), which mediates many of growth hormone's anabolic effects

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To mitigate these effects, the dosing schedule involves a slow, gradual escalation, typically increasing the weekly dose by 2.5 mg every four weeks, which the multi-dose 60mg vial must be accurately administered to follow

Document 6 : volution de la glycmie et des concentrations sanguines en glucagon et en insuline aprs un repas chez 15 sujets traits ou non pendant 3 mois avec du smaglutide