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Its levels decline with age, which correlates with reduced skin repair, slower hair growth, and increased signs of aging

P., Lobisch, M., Schtte, K., & Gries, F

H.HuwylerJ.et al (2013)

In IL-1-stimulated OA models, they upregulate SOX9 and COMP while suppressing ADAMTS4 activity, and micro-CT analysis shows 35% less subchondral bone loss

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