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Of note, even before the introduction of the newer classes of medications, multifactorial, target-driven therapies addressing glycaemic, blood pressure and lipid control that incorporated reninangiotensin system blockade, the use of statins and attention to lifestyle factors significantly reduced the progression to end-stage kidney disease by about 50% in people with type 2 diabetes, hypertension and microalbuminuria

Nature 379: 69-72, 1996

Like all treatments, Semaglutide GLP-1 can cause side effects such as constipation, diarrhea, and nausea, which usually subside as the body adjusts

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