While the incidence of PKU has remained steady at around 1 in 11,400 live births in the United States (59), newborn screening and the early institution of various treatment modalities have greatly reduced the number of severely affected individuals
Because pKa influences: Stability Reactivity Antioxidant capacity Glutathiones thiol group (from cysteine) is crucial for neutralizing free radicals
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Taguchi K, Takaku M, Egner PA, Morita M, Kaneko T, Mashimo T, et al