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How Do Preclinical and Animal Models Support Clinical Findings

On the other hand, with the introduction of KGN or TA, the degeneration of cartilage tissue caused by the defects was partially inhibited by the PKG and PTA hydrogels and some calcific tissue and cartilage wear could be observed macroscopically

The genes analyzed include several types of collagen (COL1 A1, COL1 A2, COL2 A1, etc.), as well as genes involved in the synthesis of hyaluronic acid (HAS1, HAS2, HAS3) and elastin (ELN)