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Receptor target dictates what the data actually mean, because different receptors activate different downstream signalling cascades

Indeed, RYGB, which causes marked gastrointestinal distension due to how it forces food passage through the reconfigured gastrointestinal tract, leads to the same central pattern of neuronal activation as activating GLP-1R-expressing and OXR-expressing vagal afferents in mice [31, 36, 37], while vagotomy partially prevents the appetite suppression and weight loss caused by RYGB in rats [38]

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this area attracts attention from researchers studying tissue support, recovery speed, performance output, and the broader repair response