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In contrast, patients who switched to phentermine after losing at least 20 pounds while on a GLP-1 receptor agonist were more likely to regain weight 1 year after discontinuing the GLP-1 medication, with more than half regaining at least some of their weight
These drugs work by mimicking a hormone (called GLP-1) that helps your body regulate blood sugar and hunger signals
There is enormous exuberance about starting GLP-1 drugs, but not nearly enough attention to what happens when people stop, said senior author Ziyad Al-Aly, MD, a WashU Medicine clinical epidemiologist and chief of the Research and Development Service at the VA Saint Louis Health Care System