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A 2024 assessment of registered clinical trials on L-Arginine and L-Citrulline interventions for hypertension - published in the journal Pharmaceuticals - found significant heterogeneity in the existing evidence, noting that inconsistencies in study design make it difficult to precisely quantify effect size, and that not all translational studies may have influenced vascular reactivity in the same way

New England Journal of Medicine , May 2025

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