When DEGs were cross-referenced to a metabolic gene list (2,921 genes) compiled from previously published studies 6,32 , we observed significant overrepresentation of metabolic DEGs, as determined by Fishers exact test (Extended Data Fig
Just for example, if there's an activity where I knew I was going to have to maybe do a whole lot of walking or something like that, it would be, hey, I'll just wait in the car or something like that
DSIP appears to help break this cycle through multiple mechanisms
Physiotherapy plays a vital rolebut there are limits depending on the cause of the locking: Physiotherapy can help if: Locking is due to muscle guarding , pain , or swelling (pseudo-locking) Symptoms are mild or intermittent The tear is stable and not displaced Physiotherapy cannot fix : True mechanical locking caused by a displaced meniscus fragment Bucket-handle tears that are physically obstructing joint movement In those cases, urgent surgical referral is necessary to avoid further damage
typically administered in cycles of 4-8 weeks
