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Methods To elucidate the role of FGF21 in regulating SLC25A39-dependent mitochondrial GSH transport and providing protection against TBI-induced neurological deficits, a series of cellular and molecular techniques, including western blot analysis, real-time polymerase chain reaction, immunohistochemistry, transmission electron microscope, and behavioral assays, were employed

Conversely, the mitochondrial damage and calcium homeostasis imbalance triggered by NLRP3 activation further exacerbate mtROS production, creating a positive feedback amplification loop

Why is our Gut Microbiome So Important