The study of pernicious anemia patients with relapse of anemia (Figure 10) (53) has shown that the depletion of serum vitamin B-12 after folic acid administration is accompanied by a proportional increase in reticulocyte counts, suggesting that serum vitamin B-12 is diverted into the hematopoietic system to provide the necessary vitamin B-12 coenzyme for methionine production
Among NSAIDs, naproxen may carry a somewhat lower cardiovascular risk, while diclofenac and COX-2 inhibitors often show higher risk
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