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Studies of people using GLP-1 medications who incorporated progressive strength work maintained significantly more lean mass than those who only dieted

A network-meta-analysis showed that phentermine/topiramate and semaglutide were the most efficacious therapeutic options in terms of BW reduction 11

Animal studies and a very small uncontrolled human pilot study exist

Dehydration and electrolyte depletion The gastrointestinal side effects of tirzepatide, nausea in 24% to 31% of users, diarrhea in 18% to 23%, vomiting in 8% to 12%, create fluid and electrolyte losses that many people do not adequately replace

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