There is also an increased sensitization of the excitatory neurotransmitter system, such as NMDA glutamate receptors, the reduction in the number of GABA receptors (downregulation), the shift of benzodiazepine receptors to an inverse agonist state, and compensatory changes in other components of the macromolecular GABA/benzodiazepine/chloride ionophore complex (for review see, i.e., [219,220,221,222,223,224,225])
5 (download XLSX Statistical Source Data Unprocessed western blots Source Data Fig
Activation of the contractile apparatus is responsible for the loss and disorganization of dense tight junction (TJ) proteins, which consecutively lead to BBB breakdown (60)
Yes, most side effects are noticeable in the early stages of treatment and tend to settle over time
AW designed the study, analyzed the data, wrote the article