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In a randomized controlled trial in 72 subjects with migraine, 50,000 IU (1,250 mcg) of oral vitamin D every two weeks plus a daily multi-strain probiotic providing 450 billion colony forming units (CFUs) for 12 weeks reduced the frequency and severity of migraines (Tirani 2024)

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The use of GLP1s was initially pioneered by bodybuilders in the late 2010s, who discovered that the medication could help with weight loss, and this led to further research and development of the drug for obesity treatment 4m10s