Although GLP-1s are generally safe for the liver, its important to check, especially before compounded meds Kidney function: to watch for stress on the kidneys, which can be exacerbated by GLP-1-induced dehydration and nausea, especially in older adults or those with preexisting conditions [1] Thyroid markers : to screen for an under-functioning thyroid gland, which can mimic or worsen weight gain
Debjani further says that while the individual ingredients in Lemme GLP-1 Daily seem safe and are naturally derived, there are no studies on the specific combination of all three ingredients. She mentions that it can cause some adverse effects including gastrointestinal distress like diarrhoea, gas and bloating
Information on active UK trials can be found via the following resources: NIHR Be Part of Research (bepartofresearch.nihr.ac.uk) a UK-specific portal for finding clinical trials ISRCTN registry (isrctn.com) ClinicalTrials.gov (clinicaltrials.gov) Scientific References TripleHormone-Receptor Agonist Retatrutide for Obesity Phase 2 Trial
That said, if youre microdosing a GLP-1 under guidance of a knowledgeable provider, they will ensure you are still hitting your one-to-two pound weekly weight loss even on a smaller dose
Researchers who have experience with semaglutide dosing or tirzepatide dosing sometimes assume that retatrutide titration can be more aggressive because of their prior experience with GLP-1 receptor activation
