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doi:10.1016/j.ajpath.2014.12.012

Methods: We surveyed preclinical and clinical studies investigating the impact of vitamin D and exercise on neurotrophic signaling (e.g., BDNF, IGF-1), vascular and inflammatory pathways (e.g., VEGF, cytokines), and cognitive or functional outcomes in aging models and older human populations

How it Works GLP-1 agonists mimic the actions of the naturally occurring GLP-1 incretin hormone, released in response to food intake

They attain this by inhibiting the intracellular accumulation of Reactive Oxygen Species (ROS) and increasing the expression of glutathione peroxidase and superoxide dismutase, thus improving the adverse cellular changes induced by ROS