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Sometimes, constipation can also shift to urgent diarrhea, says Ortiz-Pujols

GLP-1 Bone Mineral Density Research: Semaglutide and Tirzepatide Skeletal Effects Data A 2026 matched-cohort study found significant hip and femoral neck bone density loss after 17 months of semaglutide or tirzepatide use in 510 patients

GLP-1 treatments can also reduce the effectiveness of oral contraceptives

Effects of semaglutide on risk of cardiovascular events across a continuum of cardiovascular risk: combined post hoc analysis of the SUSTAIN and PIONEER trials